![]() Methods for the detection of fentanyl and other opioids, explosives, rodenticides, and even alcoholic beverages have been established. To assist laboratories in these efforts, a suite of methods for the analysis of different compound and sample types has been, and continues to be, developed. The database, which can be downloaded at, can used with NIST MS Search software or is available as a general-purpose structure data file (.SDF) ( doi.org/10.18434/mds2-2313) or with the newly released DIT.ĭevelopment of methods for the analysis of different sample types is often one of the first things that needs to occur with the implementation of a new technique. The database, which is freely available and regularly updated, provides mass spectra for over 800 compounds. seized drugs, cutting agents, etc.) collected either by NIST scientists or by collaborating laboratories. The database is an evaluated collection of mass spectra of compounds of interest to the forensics community (e.g. ![]() To complement the DIT, the NIST DART-MS Forensics Database has also been created. As additional functionalities are built in, updates to the DIT will be made available. The DIT is open source and vendor agnostic. Reporting and library viewing capabilities are also included. The first version of the DIT was released in October 2021 and provides the ability to search one or more is-CID mass spectra against a spectral library. The NIST/NIJ DART-MS Data Interpretation Tool (DIT) is the central component of this effort. To assist forensic laboratories with these efforts, the development of a suite of data analysis tools is underway that will provide spectral databases, spectral searching, and other features. Additionally, as with all mass spectrometry techniques, identification of compounds is often completed by comparing a sample mass spectrum to a library of known mass spectra. While AI-MS techniques such as DART-MS are capable of rapidly analyzing samples, examining the resulting data can be time-consuming and cumbersome. ![]() Spectral Databases, Search Software, and Data Analysis Tools *ANY MENTION OF COMMERCIAL PRODUCTS WITHIN NIST WEB PAGES IS FOR INFORMATION ONLY IT DOES NOT IMPLY RECOMMENDATION OR ENDORSEMENT BY NIST. Through these efforts we aim to provide these key needs to the community. These efforts are aimed at addressing many of the common roadblocks for adoption of new technologies by forensic laboratories including development of instrumental methods, validation procedures, workflows, spectral databases, and data analysis tools. The development of methods, software tools, and resources for forensic laboratories using DART-MS or other AI-MS techniques is a collaborative effort between the Surface and Trace Chemical Analysis Group (STCAG), the Mass Spectrometry Data Center (MSDC), and practicing forensic laboratories across the country. If you have any questions, please contact DARTdata. This project is part of NIST’s ongoing effort to help labs detect and identify synthetic opioids and other drugs efficiently, reliably, and safely. 2022): The 6 th update (Firefly) to the NIST DART-MS Forensics Database has been released and is available for download from the NIST Public Data Repository. 2022): V ersion 2.0 of the the NIST/NIJ DART-MS Data Interpretation Tool has been released and is available for download from the NIST Public Data Repository. These resources can be adopted, and adapted, by laboratories as needed, to fit the scope of their analyses. To assist in the adoption and implementation of these techniques in forensic laboratories, we are developing a suite of methods, software tools, and resources, including databases, mass spectral search tools, analytical methods, and example validation documents. With increasing backlogs and more complex samples, forensic chemistry laboratories need new technologies that rapidly provide accurate results. Many laboratories are adopting ambient ionization mass spectrometry (AI-MS) tools such as direct analysis in real time mass spectrometry (DART-MS) to meet this need. These techniques enable laboratories to obtain mass spectra, or molecular “fingerprints,” from samples in seconds instead of tens of minutes. Because these techniques are highly sensitive, very little of the sample is handled or consumed during analysis, reducing accidental exposure risks when analyzing highly toxic compounds.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |